Bioprocessing

Simplify bioprocess monitoring with the Andrew+ Robot and OneLab Software. This intuitive walk-up solution automates sample prep and simplifies LC-MS analysis, enabling bioprocess engineers to quickly generate high-quality data for attributes such as intact mass, glycosylation profile, and cell culture media composition with ease— all without requiring LC-MS or automation expertise.

Overview

Bioprocess engineers are under increasing pressure to deliver faster insights while navigating complex upstream workflows. Waters Bioprocess Walk-Up Solutions turn this challenge into a competitive advantage with a fully automated, sample-to-result LC-MS workflow. Leveraging the Andrew+ Robot and OneLab Software, our solutions simplify sample prep and enable effortless monitoring of intact protein mass, spent media composition, and glycosylation profiles. Seamlessly integrated with bioreactors, this intuitive platform boosts throughput, minimizes manual steps, and accelerates confident, data-driven decisions.

Boost your Bioprocessing with the Andrew+ Robot, your trusted lab automation partner

Bioprocess engineers face mounting pressure to deliver faster insights from increasingly complex upstream workflows. With limited time to master LC-MS, lab automation, and coding, they need a smarter solution. The Waters Bioprocess Walk-Up Solutions transforms this challenge into a competitive edge with a fully automated, sample-to-result LC-MS workflow. Powered by the Andrew+ Robot and OneLab Software, it streamlines sample prep and enables effortless analysis of intact protein mass, spent media composition, and glycosylation profiles. Seamless integration with bioreactors boosts throughput, reduces manual steps, and accelerates confident, data-driven decisions, all without the need for specialized expertise.

Bioprocess development increasingly relies on timely and accurate characterization of critical quality attributes (CQAs) such as intact protein mass, glycosylation profiles, and cell culture media composition. Yet, the complexity of LC-MS workflows and the need for specialized expertise can limit accessibility. To address this, a fully automated, walk-up LC-MS workflow has been developed, integrating liquid handling via the Andrew+ Robot, with analytical capabilities of the BioAccord LC-MS System, and protocol management through OneLab Software. The approach supports enhanced process understanding and robustness contributing to efficient upstream development, consistent, reliable results, and reduced time to decision-making.

Streamline your bioprocess monitoring with OneLab Software

Simplify complex biomonitoring studies with OneLab Software, your intuitive, no-code platform for automated bioprocessing. Whether you’re analyzing intact mass, cell culture media composition, or glycosylation profiles, OneLab Software and the Andrew+ Robot streamline your workflows with precision and ease.

  • Create and share protocols effortlessly with our visual interface.
  • Make smarter decisions with instant access to critical quality attributes (CQAs).
  • Reduce manufacturing costs while ensuring GxP compliance, secure access, and full traceability.

From validation to innovation, OneLab Software enables your team to focus on bioprocess monitoring while it handles the automation.

Solutions

Andrew+ Robot: your catalyst for faster, smarter bioprocessing

Andrew+ Robot revolutionizes bioprocessing with automated LC-MS sample prep, delivering fast, expert-level insights on therapeutic proteins, cell culture, media, glycosylation profile, and much more, without coding or specialized training.

Unlock the future of bioprocess monitoring

Simplify bioprocess automation with OneLab Software: a no-code platform for designing, executing, and analyzing biomonitoring studies with fast, accurate, compliant, and accessible from any device. Access experimental design and execution right at your fingertips.

Applications

Bioprocessing

These application notes demonstrate the capabilities of Waters Bioprocess Walk-Up Solutions. Featured workflows include automated antibody purification from cell culture media using Protein A-coupled magnetic beads in just 35 minutes, and a rapid nine-minute LC-MS method for profiling over 220 nutrients and metabolites. Together, these tools streamline sample preparation, enhance reproducibility, and enable early access to product quality and media composition data.

The data speaks for itself

Comparison of antibody recovery using manual pipetting (n=4) versus the Andrew+ Robot (n=4 and n=8). Average recovery values are indicated by (x) markers, highlighting the consistency of automated workflows.
Summary of linear range, accuracy, and precision of amino acids and glucose quantification using the nine-minute method. Amino acid standard solution used in the analysis is the amino acid cell culture standard kit (p/n: 186009300). The linear range is derived from linear regression with 1/x2 fitting, 20% deviation was used as the exclusion criteria. Amino acids data were acquired using ESI+ and glucose using ESI- mode of acquisition.
Left panel (a): Day 10 harvested sample, UV chromatogram with spectra for light chain and main IgG peak. Right panel (b): Day 10 protein A purified sample, showing IgG.