DMPK: Automated Sample Preparation

Automated Sample Preparation

If you’re focused on bioanalytical method development to support DMPK studies for small molecule drugs, you can rely on Waters as your single-source solution for automated sample preparation, enhancing your laboratory’s productivity and allowing you to concentrate on critical issues while minimizing costly errors.

Overview

Tackle your most complex DMPK challenges confidently with Waters proven solutions. For decades, chemists developing breakthrough small molecule drugs have relied on Waters. The Andrew+ Robot powered by OneLab Software eliminates the need for manual generation of standard curves and other tedious tasks like plate reformatting and concentration normalization. Further, the Andrew+ Robot allows the rapid evaluation of multiple solid phase extraction (SPE) sorbents and elution conditions for your analyte and matrix of interest, significantly accelerating bioanalytical method development.

Streamline your sample preparation process for small molecule DMPK studies with the Andrew+ Robot with its remarkable efficiency. It features:

  • intuitive protocol design
  • straightforward setup
  • step-by-step guidance with Click & -Execute Methods
  • robust data integrity compliance


Waters automated sample preparation can not only enhance your laboratory productivity but also ensure accurate, reliable results that uphold product quality and safeguard patient well-being.

Easy, automated sample prep to accelerate small molecule bioanalytical method development

Developing new bioanalytical methods to support DMPK studies involves screening multiple SPE sorbents with different chemistries and elution conditions as part of SPE method development. This process is tedious, time-consuming, and error-prone due to multiple, repetitive pipetting steps involved.

The Andrew+ Robot and OneLab Software have revolutionized bioanalytical method development for small molecule drugs, making automation seamless and efficient. With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency and data integrity compliance while delivering accurate, reliable results to ensure patient safety.

Easily design and execute studies to accelerate bioanalytical method development from your own PC or tablet

Easily automate SPE sample prep for bioanalytical method development with OneLab Software; no need to be a software expert. Its intuitive drag-and-drop interface automates the analysis of small molecules preparation, so DMPK studies have never been easier. Plus, help is always available through the embedded chat feature.

OneLab Software’s tools simplify calculating dilution factors and designing serial dilutions without error. For many common bioanalytical workflows, you’ll find the protocols you need in the OneLab Software online protocol library. Download methods developed by experts to get started, modify the methods to suit your specific needs, and experience automation with ease. OneLab Software supports all your data integrity compliance needs for seamless bioanalytical method development.

Solutions

Easy, Automated Sample Prep on the Andrew+ Robot to Accelerate Small Molecule Bioanalytical Method Development

With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple small molecule sample prep workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety. 

Intuitive Protocol Development for Small Molecule Bioanalytical Method Development with OneLab Software

Creating automated sample prep protocols for small molecule bioanalytical studies has never been easier, thanks to OneLab Software’s intuitive drag-and-drop interface. You can access help through the embedded chat, download protocols from the online library, and rely on robust data integrity compliance. These are just a few of the ways OneLab Software simplifies automated small molecule drug sample prep.

Applications

Small Molecule Bioanalysis Studies

Enhance the productivity of your Small Molecule Bioanalytical Laboratory with robust, easy-to-deploy automated sample preparation using the Andrew+ Robot

The Andrew+ Robot configured with the required dominos, the Waters Bluetooth electronic pipettes and microplate gripper on the tool stand and the Extraction+ Connected Device including the connected vacuum pump, flow-through waste container, Extraction+ manifold for plate or cartridge extraction with the manifold collar and the integrated collar lifter.

The Andrew+ Robot workbench layout and configuration for automating the Oasis 2×4 SPE Sorbent Selection Method, as shown in OneLab Software.

The Extraction+ Connected Device showing the integrated vacuum pump (1), the flow-through waste collection bottle (2), Domino with sample collection racks (3), the extraction manifold (4)

Graphical illustration of the automated SPE sample extraction and LC-MS analysis workflow using Oasis HLB SPE plates and cartridges and the Andrew+ Robot configured with the Extraction+ Connected Device.

The OneLab Software method’s equipment list and protocol visualization for sample dilutions are shown above. Pipettes, pipette tips, Dominos, and labware required are shown on the right side.

Extraction of Apixaban using Oasis MCX 96-well plate. The OneLab Software’s protocol visualization of an SPE method is shown. Individual samples are color coded in the 96-well sample plate in the upper left and the final target plate is designated at the lower right of the figure.

The data speaks for itself