Endotoxin Testing

Automated Sample Preparation

Trust Waters to automate your endotoxin testing with ease using the Andrew+ Robot. Gain efficiency through OneLab Software’s simple setup, Click & Execute Methods for multiple testing reagent kits, Dynamic Protocols for varying number of samples, and built-in data integrity compliance. Leave the automation to Andrew+ Robot so you can save time and focus on your results with Waters support.

Automated Sample Preparation

Endotoxin testing is essential for safely bringing injectable drugs and medical devices to market. The traditional process is tedious and time-consuming, requiring multiple pipetting steps to generate standard curves with positive product controls (PPCs) before analyzing test samples. Trust Waters as your single source for sample preparation solutions. The Andrew+ Robot, powered by OneLab Software, automates these steps with ease, offering simple set-up, Click & Execute Methods that support multiple testing platforms, and built-in data integrity compliance. enhance lab efficiency while delivering accurate, reliable results that help ensure product quality and patient safety.

Andrew Pipetting and Liquid Handling Robot

Simplified and automated endotoxin testing with Andrew+ Robot for accurate results

New testing platforms based on Recombinant Factor C (rFC) and Recombinant Cascade Reagent (rCR) have transformed endotoxin testing, a process essential to safely delivering injectable drugs and medical devices to patients worldwide. Yet, the endotoxin testing process remains tedious, time-consuming, and error-prone due to multiple, repetitive pipetting steps involved in running the assays. The Andrew+ Robot, powered by OneLab Software, has revolutionized endotoxin testing, making automation with ease a reality. With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple testing platforms, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results.

Notes on the diagrams

Endotoxin is a major constituent of the outer membrane of gram-negative bacteria. A) Gram-negative cell envelope © Jeff Dahl, CC BY-SA 4.0 via Wikimedia Commons (5). B) Endotoxin structural schematic, CC BY 3.0 (6).

Standard Curves for Pyrochrome® executed by the Andrew+ Robot using this OneLab Software protocol.

Sample PPC and recovery results for Pyrochrome executed by the Andrew+ Robot using this OneLab Software protocol. Forty-two data points were collected over 14 plates for each sample and PPC.

Effortlessly design and execute endotoxin testing protocols from your PC or tablet using OneLab Software

No need to be a software engineer to write sophisticated endotoxin testing protocols —OneLab Software makes it simple. Its intuitive drag-and-drop interface makes creating automated endotoxin testing protocols easier than ever. Plus, help is always available through the embedded chat feature. OneLab Software’s tools simplify complex tasks like calculating dilution factors and designing serial dilutions, reducing the risk of error. Often, the endotoxin testing protocols you need are already available in the OneLab Software online protocol library. Download Click & Execute Methods for the PyroSmart NextGen® or Pyrochrome® test kits and follow the step-by-step instructions to set up your workflow. Rest assured, OneLab Software supports all your data integrity compliance needs, making endotoxin testing effortless.

Solutions

Easy, automated endotoxin testing on the Andrew+ Robot

With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple endotoxin testing platforms, and data integrity compliance, Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety.

Andrew Pipetting and Liquid Handling Robot
Laboratory Protocols

Easy endotoxin testing protocol development with OneLab Software

Creating automated endotoxin testing protocols has never been easier thanks to OneLab Software’s intuitive drag-and-drop interface. You can access help through the embedded chat, download protocols from the online library, and rely on robust data integrity compliance—just a few of the ways OneLab Software simplifies automated endotoxin testing.

Applications

Fungitell® Glucan Detection Assay

The Fungitell® chromogenic assay is used to detect (1→3)-β-D-Glucan, a biomarker for invasive fungal disease. The Limulus Amebocyte Lysate (LAL) based assay requires a complex plate building process with numerous sample handling and pipetting steps including standard curve preparation, control testing, in-plate sample pretreatment, and reagent dispensing.

PyroSmart NextGen® Recombinant Cascade Reagent (rCR) for Endotoxin Detection

PyroSmart NextGen® is a 96 well microplate based chromogenic that utilizes recombinant proteins as key inputs. The assay requires a complex plate-building process with numerous pipetting steps. Standard curve and positive product control (PPC) preparation, sample arraying, and reagent dispensing are time-consuming and tedious steps that can be accomplished using an Andrew+ Robot.

Pyrochrome® Endotoxin Detection Assay

 Pyrochrome® is a 96 well microplate based chromogenic Limulus Amebocyte Lysate (LAL) assay that requires a complex plate building process with numerous pipetting steps. Standard curve and positive product control (PPC) preparation, sample arraying, and reagent dispensing are time consuming and tedious steps that can be accomplished using an Andrew+ Robot.

Applications

Standard curves for Pyrochrome® executed by Andrew+ Robot using this OneLab Software protocol.

Pyrochrome® is a 96 well microplate based chromogenic Limulus Amebocyte Lysate (LAL) assay that requires a complex plate building process with numerous pipetting steps. Standard curve and positive product control (PPC) preparation, sample arraying, and reagent dispensing are time consuming and tedious steps that can be accomplished using an Andrew+ Robot.