Small Molecule Drugs

Automated Sample Preparation

Streamline your bioanalytical development or QA/QC workflows with Waters – your trusted partner for small molecule therapies. Rely on Waters as your single-source solution for automated sample preparation, enhancing your laboratory’s productivity and allowing you to concentrate on critical issues while minimizing costly errors.

Overview

For decades, chemists developing breakthrough small molecule drugs have relied on Waters solutions to tackle their most complex analytical challenges. If you’re a QA/QC chemist working with small molecules, the Andrew+ Robot powered by OneLab Software eliminates the need for manual generation of standard curves and other tedious tasks like plate reformatting and concentration normalization. For those focused on DMPK, the Andrew+ Robot allows rapid evaluation of multiple SPE sorbents and elution conditions for your analyte of interest, significantly accelerating SPE method development.

The Andrew+ Robot powered by OneLab Software streamlines the sample preparation process for small molecule drugs with remarkable efficiency. Its features include:

  • intuitive protocol design
  • straightforward setup
  • step-by-step guidance with Click & Execute Methods
  • robust data integrity compliance

Waters automated sample preparation can not only enhance laboratory productivity but also ensure accurate, reliable results that uphold product quality and safeguard patient well-being.

Easy, automated sample prep to accelerate small molecule assay development on the Andrew+ Robot

To ensure the efficacy and safety of small molecule drugs, repetitive, error prone tasks such as standard curve generation, plate reformatting, and concentration normalization are performed on a routine basis. Developing new bioanalytical methods to support DMPK studies involve screening multiple SPE sorbents and elution conditions as part of SPE method development. These tasks are tedious, time-consuming, and error-prone due to multiple, repetitive pipetting steps involved.

The Andrew+ Robot powered by OneLab Software has revolutionized the analysis of small molecule drugs, making automation with ease a reality. With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety.

Easily design and execute studies to analyze small molecule therapies from your own PC or tablet

Easily automate SPE sample prep for small molecule drug studies with OneLab Software – with no need to be a software expert. Its intuitive drag-and-drop interface automates the characterization of small molecules, so it’s never been easier. Plus, help is always available through the embedded chat feature.

OneLab Software’s tools simplify calculating dilution factors and designing serial dilutions without error. For common applications like SPE, you’ll find the protocols you need in the OneLab Software online protocol library. Download methods developed by experts to get started, modify the methods to suit your specific needs, and experience automation with ease. OneLab Software supports all your data integrity compliance needs for seamless small molecule analysis.

Solutions

Easy, Automated Sample Prep on the Andrew+ Robot to Accelerate Small Molecule Drug Analysis

With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple small molecule analysis workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety.

Intuitive Protocol Development for Small Molecule Drug Sample Prep with OneLab Software

Creating automated sample prep protocols for small molecule drug analysis has never been easier, thanks to OneLab Software’s intuitive drag-and-drop interface. You can access help through the embedded chat, download protocols from the online library, and rely on robust data integrity compliance—just a few of the ways OneLab Software simplifies automated small molecule drug sample prep.

Applications

Small Molecule Drug Analysis Studies

Enhance the productivity of your Small Molecule Analytical Laboratory with robust, easy-to-deploy automated sample preparation using the Andrew+ Robot.

The data speaks for itself

Percentage recovery of the analytes from four replicate spiked human blood plasma for the four Oasis mixed-mode SPE sorbents using (A) ELUTE-2 and (B) ELUTE-1 steps of the protocol.
Accuracy and precision results from QC samples prepared by the Andrew+ Robot and extracted using the Extraction+ connected device from an Oasis HLB 96-well plate (N=3).
LC-MS quantitative performance of itaconic acid extracted from plasma with Ostro PPT and Phospholipid Removal Plates using the Andrew+ Robot.
Chromatographic separation of apixaban using the ACQUITY UPLC BEH C18 Column (1.7 µm, 2.1 mm x 50 mm) and the conditions described in the experimental section. Panel A highlights the extracted low calibration standard (2 ng/mL) as compared to the extracted blank plasma sample, while Panel B highlights the chromatographic performance for the low (4 ng/mL), mid (40 ng/mL), and high (400 ng/mL) plasma extracted QC samples. For both data sets plasma samples were extracted using the Oasis MCX 96-well SPE plate using the Andrew+ Robot configured with the Extraction+ Connected Device.
Representative recovery and matrix effects resulting from the extraction of Apixaban from plasma using the techniques listed above.