Small Molecule Drugs

Automated Sample Preparation

Streamline your bioanalytical development or QA/QC workflows with Waters – your trusted partner for small molecule therapies. Rely on Waters as your single-source solution for automated sample preparation, enhancing your laboratory’s productivity and allowing you to concentrate on critical issues while minimizing costly errors.

Overview

For decades, chemists developing breakthrough small molecule drugs have relied on Waters solutions to tackle their most complex analytical challenges. If you’re a QA/QC chemist working with small molecules, the Andrew+ Robot powered by OneLab Software eliminates the need for manual generation of standard curves and other tedious tasks like plate reformatting and concentration normalization. For those focused on DMPK, the Andrew+ Robot allows rapid evaluation of multiple SPE sorbents and elution conditions for your analyte of interest, significantly accelerating SPE method development.

The Andrew+ Robot powered by OneLab Software streamlines the sample preparation process for small molecule drugs with remarkable efficiency. Its features include:

  • intuitive protocol design
  • straightforward setup
  • step-by-step guidance with Click & Execute Methods
  • robust data integrity compliance

Waters automated sample preparation can not only enhance laboratory productivity but also ensure accurate, reliable results that uphold product quality and safeguard patient well-being.

Easy, automated sample prep to accelerate small molecule assay development on the Andrew+ Robot

To ensure the efficacy and safety of small molecule drugs, repetitive, error prone tasks such as standard curve generation, plate reformatting, and concentration normalization are performed on a routine basis. Developing new bioanalytical methods to support DMPK studies involve screening multiple SPE sorbents and elution conditions as part of SPE method development. These tasks are tedious, time-consuming, and error-prone due to multiple, repetitive pipetting steps involved.

The Andrew+ Robot powered by OneLab Software has revolutionized the analysis of small molecule drugs, making automation with ease a reality. With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety.

Easily design and execute studies to analyze small molecule therapies from your own PC or tablet

Easily automate SPE sample prep for small molecule drug studies with OneLab Software – with no need to be a software expert. Its intuitive drag-and-drop interface automates the characterization of small molecules, so it’s never been easier. Plus, help is always available through the embedded chat feature.

OneLab Software’s tools simplify calculating dilution factors and designing serial dilutions without error. For common applications like SPE, you’ll find the protocols you need in the OneLab Software online protocol library. Download methods developed by experts to get started, modify the methods to suit your specific needs, and experience automation with ease. OneLab Software supports all your data integrity compliance needs for seamless small molecule analysis.

Solutions

Easy, Automated Sample Prep on the Andrew+ Robot to Accelerate Small Molecule Drug Analysis

With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple small molecule analysis workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety.

Intuitive Protocol Development for Small Molecule Drug Sample Prep with OneLab Software

Creating automated sample prep protocols for small molecule drug analysis has never been easier, thanks to OneLab Software’s intuitive drag-and-drop interface. You can access help through the embedded chat, download protocols from the online library, and rely on robust data integrity compliance—just a few of the ways OneLab Software simplifies automated small molecule drug sample prep.

Applications

Small Molecule Drug Analysis Studies

Enhance the productivity of your Small Molecule Analytical Laboratory with robust, easy-to-deploy automated sample preparation using the Andrew+ Robot.

The Andrew+ Robot configured with the required dominos, the Waters Bluetooth electronic pipettes and microplate gripper on the tool stand and the Extraction+ Connected Device including the connected vacuum pump, flow-through waste container, Extraction+ manifold for plate or cartridge extraction with the manifold collar and the integrated collar lifter.

The Andrew+ Robot workbench layout and configuration for automating the Oasis 2×4 SPE Sorbent Selection Method, as shown in OneLab Software.

The Extraction+ Connected Device showing the integrated vacuum pump (1), the flow-through waste collection bottle (2), Domino with sample collection racks (3), the extraction manifold (4)

Graphical illustration of the automated SPE sample extraction and LC-MS analysis workflow using Oasis HLB SPE plates and cartridges and the Andrew+ Robot configured with the Extraction+ Connected Device.

The OneLab Software method’s equipment list and protocol visualization for sample dilutions are shown above. Pipettes, pipette tips, Dominos, and labware required are shown on the right side.

Extraction of Apixaban using Oasis MCX 96-well plate. The OneLab Software’s protocol visualization of an SPE method is shown. Individual samples are color coded in the 96-well sample plate in the upper left and the final target plate is designated at the lower right of the figure.

The data speaks for itself