Discovery bioanalysis labs are under constant pressure to deliver high-quality data to support fast-moving programs with chemically diverse candidates. Scientists must balance speed, cleanliness, and cost when selecting workflows that perform reliably across a broad analyte space. In this webinar, we present an optimized, end-to-end workflow featuring an Oasis PRiME HLB two-step protocol, a prototype ultrashort UPLC column, and a robust LC-MS platform. From sample prep to chromatography to data processing, we demonstrate how this approach streamlines method development, improves consistency, and enhances operational efficiency, helping labs achieve high-quality results without sacrificing speed.
• Understand how to implement a simplified, end-to-end workflow for discovery bioanalysis
• Evaluate how a two-step Oasis PRiME HLB protocol—compared to protein precipitation—improves outcomes beyond sample cleanliness, including system pressure, area count stability, data quality, and column lifetime
• View the benefits of ultrashort UPLC columns for achieving high-throughput separations coupled with a robust MS platform for drug discovery labs
• Recognize how each component of the workflow can influence speed, cleanliness, reproducibility, data quality, and overall cost
