DMPK: Automated Sample Preparation

Automated Sample Preparation

If you’re focused on bioanalytical method development to support DMPK studies for small molecule drugs, you can rely on Waters as your single-source solution for automated sample preparation, enhancing your laboratory’s productivity and allowing you to concentrate on critical issues while minimizing costly errors.

Overview

Tackle your most complex DMPK challenges confidently with Waters proven solutions. For decades, chemists developing breakthrough small molecule drugs have relied on Waters. The Andrew+ Robot powered by OneLab Software eliminates the need for manual generation of standard curves and other tedious tasks like plate reformatting and concentration normalization. Further, the Andrew+ Robot allows the rapid evaluation of multiple solid phase extraction (SPE) sorbents and elution conditions for your analyte and matrix of interest, significantly accelerating bioanalytical method development.

Streamline your sample preparation process for small molecule DMPK studies with the Andrew+ Robot with its remarkable efficiency. It features:

  • intuitive protocol design
  • straightforward setup
  • step-by-step guidance with Click & -Execute Methods
  • robust data integrity compliance

Waters automated sample preparation can not only enhance your laboratory productivity but also ensure accurate, reliable results that uphold product quality and safeguard patient well-being.

Easy, automated sample prep to accelerate small molecule bioanalytical method development

Developing new bioanalytical methods to support DMPK studies involves screening multiple SPE sorbents with different chemistries and elution conditions as part of SPE method development. This process is tedious, time-consuming, and error-prone due to multiple, repetitive pipetting steps involved.

The Andrew+ Robot and OneLab Software have revolutionized bioanalytical method development for small molecule drugs, making automation seamless and efficient. With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency and data integrity compliance while delivering accurate, reliable results to ensure patient safety.

Easily design and execute studies to accelerate bioanalytical method development from your own PC or tablet

Easily automate SPE sample prep for bioanalytical method development with OneLab Software; no need to be a software expert. Its intuitive drag-and-drop interface automates the analysis of small molecules preparation, so DMPK studies have never been easier. Plus, help is always available through the embedded chat feature.

OneLab Software’s tools simplify calculating dilution factors and designing serial dilutions without error. For many common bioanalytical workflows, you’ll find the protocols you need in the OneLab Software online protocol library. Download methods developed by experts to get started, modify the methods to suit your specific needs, and experience automation with ease. OneLab Software supports all your data integrity compliance needs for seamless bioanalytical method development.

Solutions

Easy, Automated Sample Prep on the Andrew+ Robot to Accelerate Small Molecule Bioanalytical Method Development

With its simple setup, step-by-step guidance, Click & Execute Methods supporting multiple small molecule sample prep workflows, and data integrity compliance, the Andrew+ Robot will enhance your lab’s efficiency while delivering accurate, reliable results to ensure product quality and patient safety. 

Intuitive Protocol Development for Small Molecule Bioanalytical Method Development with OneLab Software

Creating automated sample prep protocols for small molecule bioanalytical studies has never been easier, thanks to OneLab Software’s intuitive drag-and-drop interface. You can access help through the embedded chat, download protocols from the online library, and rely on robust data integrity compliance. These are just a few of the ways OneLab Software simplifies automated small molecule drug sample prep.

Applications

Small Molecule Bioanalysis Studies

Enhance the productivity of your Small Molecule Bioanalytical Laboratory with robust, easy-to-deploy automated sample preparation using the Andrew+ Robot

The data speaks for itself

Chromatographic separation of apixaban using the ACQUITY UPLC BEH C18 Column (1.7 µm, 2.1 mm x 50 mm) and the conditions described in the experimental section. Panel A highlights the extracted low calibration standard (2 ng/mL) as compared to the extracted blank plasma sample, while Panel B highlights the chromatographic performance for the low (4 ng/mL), mid (40 ng/mL), and high (400 ng/mL) plasma extracted QC samples. For both data sets plasma samples were extracted using the Oasis MCX 96-well SPE plate using the Andrew+ Robot configured with the Extraction+ Connected Device.
Representative recovery and matrix effects resulting from the extraction of Apixaban from plasma using the techniques listed above.
Percentage recovery of the analytes from four replicate spiked human blood plasma for the four Oasis mixed-mode SPE sorbents using (A) ELUTE-2 and (B) ELUTE-1 steps of the protocol.
Accuracy and precision results from QC samples prepared by Andrew+ and extracted using the Extraction+ connected device from an Oasis HLB 96-well plate (N=3).
LC-MS quantitative performance of itaconic acid extracted from plasma with Ostro PPT and Phospholipid Removal Plates using the Andrew+ Robot.