Oligonucleotide Therapies

Precision Meets Simplicity

Accelerate oligonucleotide  bioanalysis with Waters. Combine the OligoWorks Kit, Andrew+ Robot, and OneLab Software to automate complex workflows, without the need for any coding. Confidently handle diverse oligo types, including lipid-conjugated species, across plasma, urine, and tissue homogenates with precision and ease.

Overview

Oligonucleotide therapies are evolving fast, creating analytical challenges resulting from modifications, conjugates, and novel formulations. Waters simplifies your workflow with an integrated solution: the OligoWorks SPE Kit, the Andrew+ Robot for automated sample prep, and OneLab Software with click and execute protocols. Easily handle lipid-conjugated oligos across plasma, urine, and tissue homogenates. And with Waters’ GTx columns, UPLC, MS, and ProMass you can have an end-to-end solution and end-to-end confidence. Enjoy drag-and-drop protocol creation, guided compliance, and real-time support, all designed to deliver faster, more consistent results.

Elevate Oligonucleotide Bioanalysis with the Andrew+ Robot Automation Engineered for Precision, Consistency, and Throughput

The rapid growth in oligonucleotide therapeutics, including novel modalities such as antisense, siRNA, and gRNA, is pushing bioanalytical labs to deliver faster, more reliable results across complex matrices. In this high-stakes race to the clinic, sample prep errors aren’t an option.


The Andrew+ Robot powered by OneLab Software works seamlessly with OligoWorks SPE Kits to deliver detergent-free, LC-MS–ready extractions. Use click to execute protocols or build your own with intuitive drag-and-drop tools. Guided setup, built-in compliance features, and real-time support help reduce manual workload, boost productivity, and keep your lab audit-ready.

Revolutionize Oligo Bioanalysis—No Code, Just Click & Execute

OneLab Software: Simplifying LC-MS Sample Prep for Oligonucleotide Bioanalysis
Built for scientists, OneLab Software transforms complex oligonucleotide sample prep into an intuitive, automated experience.

Whether you’re analyzing antisense RNA, siRNA, or gRNA, OneLab Software and the Andrew+ Robot streamline workflows—no coding required.

From serial dilutions to method development, create and share protocols with drag-and-drop ease. Ensure GxP compliance, secure access, and full traceability while reducing manual workload. Whether you’re validating or innovating, OneLab Software empowers your team to focus on results—while it handles the automation.

Fast. Accurate. Compliant.

Support is just a click away.

Solutions

From Complex to Seamless with the Andrew+ Robot for Your Oligonucleotide Bioanalysis

Let the Andrew+ Robot reduce complexity with automated, compliant sample prep for oligonucleotide drugs that accelerates your path from sample to insight.

OneLab Software Automates Workflows for Seamless Oligo Sample Prep

OneLab Software reimagines LC-MS sample prep for oligonucleotide bioanalysis, automating workflows, ensuring compliance, and connecting teams globally. Say goodbye to complexity with intuitive, no-code automation designed by scientists, for scientists.

Applications

Automated Sample Preparation: Oligonucleotides

OligoWorks SPE Kits and the Andrew+ Robot automate oligonucleotide sample prep, delivering reproducible, LC-MS–ready results with minimal method development for consistent results you can be confident in, across diverse oligonucleotide formats.

The data speaks for itself

Achieve >96% recovery and <5% variance with automated sample prep using the Andrew+ Robot and OligoWorks Kits—delivering performance on par with manual methods for GEM91, GEM132, and GalNAc oligonucleotides. A fit-for-purpose solution for reliable, high-throughput oligo bioanalysis.
Achieve linear, accurate, and precise quantitation of GEM91, GEM132, GalNAc, and ssDNA 20-mer oligonucleotides from plasma using the OligoWorks Kit automated on the Andrew+ Robot, delivering high-performance calibration and QC results, ready for LC-MS/MS analysis.